Disponible en Dadun la tesis «Vigilancia, prevención, diagnóstico y tratamiento de las resistencias a antibióticos [beta]-lactámicos desde la perspectiva One Health», de Lara Pérez Etayo.

Resumen: Before the outbreak of the pandemic Covid-19, one of the greatest threats to medicine in the 21st century was and continues to be the antimicrobial resistances (AMR). In order to address this problem with a global perspective and taking into account the strategic lines proposed by the Spanish National Antibiotic Resistance Plan (PRAN), the general objective of this work has been to approach the surveillance, prevention, diagnosis and treatment of resistance to antibiotics, with special emphasis on the extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL). The data obtained in this Doctoral Thesis have shown that it is necessary to carry out a more effective control of the presence of MDR bacteria in the aquatic environment, implementing surveillance of relevant clonal complexes that act as markers for the presence of resistant bacteria as well as more effective wastewater treatment programs to stop the dispersion. In relation to the animal environment, a silver nanomaterial was positively evaluated as possible feed additive to replace or reduce the use of antibiotics in animal production. Finally, with regard to human health, a rapid diagnostic protocol for the detection of blaCTX-M1-producing Enterobacteriaceae was developed using the VITEK®-MS RUO equipment. In addition, the antimicrobial activity of the three tested LAB was confirmed, but further studies are necessary before considering their possible therapeutic application.

La tesis fue defendida en septiembre de 2021 y fue dirigida por Ana Isabel Vitas Pemán y David González Fernández, del departamento de Microbiología y Parasitología.